Use paper towels to pat the shrimp dry. Toss the shrimp with salt, black pepper, and garlic powder.
Gather three shallow dishes. I like to use cake pans. In one pan, add 1/2 cup flour. In another pan, add 2 eggs, lightly beaten. In the third pan, add 1 1/2 cups panko bread crumbs.
Dip each shrimp in flour, then egg, then panko bread crumbs. Use your fingers to press the bread crumbs onto each piece of shrimp.
Heat about two inches of canola or vegetable oil in a deep pot to around 350 degrees Fahrenheit.
Deep-fry the shrimp in batches, frying about 6 shrimp at a time. The shrimp will cook very quickly! When they are golden brown, use a slotted spoon to remove them from the pan, and transfer them to a paper towel lined plate. Continue cooking the shrimp in batches until all shrimp are fried and golden brown.
Serve with lemon slices and/or cocktail sauce. Enjoy!